I have had an auto transplant that kept my remission for 18 months. Finished 2nd induction and heading towards an allo transplant. Lack of a suitable donor. One doctor is considering stem cells from umbilical cord blood.
Has anyone had or heard of cord blood transplants for myeloma?
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
Re: Umbilical cord blood transplantation for myeloma?
Gracie:
I simply googled "cord blood transplant myeloma" and filtered the results based on time.
Came up with this 2010 article, but there are certainly others:
http://f1000.com/posters/browse/summary/787
You can also find clinical trials for this approach. Below is a search based on "cord blood myeloma" trials that are open:
http://clinicaltrials.gov/ct2/results?term=cord+blood+myeloma&recr=Open
I simply googled "cord blood transplant myeloma" and filtered the results based on time.
Came up with this 2010 article, but there are certainly others:
http://f1000.com/posters/browse/summary/787
You can also find clinical trials for this approach. Below is a search based on "cord blood myeloma" trials that are open:
http://clinicaltrials.gov/ct2/results?term=cord+blood+myeloma&recr=Open
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
Re: Umbilical cord blood transplantation for myeloma?
Gracie,
I started to get fascinated by the idea of cord blood transplants and just came across this. Perhaps you already found it in your own research.
http://globalnews.ca/news/1570817/molecule-boosts-stem-cells-in-cord-blood-study/
I started to get fascinated by the idea of cord blood transplants and just came across this. Perhaps you already found it in your own research.
http://globalnews.ca/news/1570817/molecule-boosts-stem-cells-in-cord-blood-study/
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Umbilical cord blood transplantation for myeloma?
Hi Gracie,
I'm not an expert, but my sense is that cord blood transplants are not done that often in myeloma and PCL patients. However, I don't think it's because there is any fundamental problem with those sort of transplants. I'm not sure they've been shown to be consistently worse, or better, than "standard" allo transplants, whether in myeloma or other blood cancers Instead, I think that the availability of stem cells from cord blood may be more limited that the availability of "standard" donated stem cells. I also wonder if there is an experience issue -- if doctors are a bit more hesitant to recommend the procedure because they just haven't done it as often.
In any case, the poster that Multibilly recommended looks like a good source of information. I also found this study from many of the same authors that discusses "double umbilical cord transplantation" in blood cancer patients -- basically, using a double dose of umbilical cord stem cells, rather than a single dose. It may be an option worth knowing about when you speak with your doctors.
HL Wallet et al., "Double umbilical cord blood transplantation for hematological malignancies: a long-term analysis from the SFGM-TC registry," Experimental Hematology, November 2013.
Abstract:
Allogeneic hematopoietic stem cell (HSC) transplantation is a curative treatment for many hematologic malignancies for which umbilical cord blood (UCB) represents an alternative source of HSCs. To overcome the low cellularity of one UCB unit, double UCB transplantation (dUCBT) has been developed in adults.
We have analyzed the outcome of 136 patients who underwent dUCBT reported to the SFGM-TC registry between 2005 and 2007. Forty-six patients received myeloablative regimens, and 90 patients received reduced-intensity conditioning regimens. There were 84 cases of leukemia, 17 cases of non-Hodgkin lymphoma, 11 cases of myeloma, and 24 other hematologic malignancies.
At transplantation, 40 (29%) patients were in complete remission. At day 60 after transplantation, the cumulative incidence of neutrophil recovery was 91%. We observed one UCB unit domination in 88% of cases. The cumulative incidence of day 100 acute graft-versus-host disease, chronic graft-versus-host disease, transplant-related mortality, and relapse at 2 years were 36%, 23%, 27%, and 28% respectively.
After a median follow-up of 49.5 months, the 3-year probabilities of overall and progression-free survival were 41% and 35%, respectively, with a significant overall survival advantage when male cord engrafted male recipients. We obtained a long-term plateau among patients in complete remission, which makes dUCBT a promising treatment strategy for these patients.
I'm not an expert, but my sense is that cord blood transplants are not done that often in myeloma and PCL patients. However, I don't think it's because there is any fundamental problem with those sort of transplants. I'm not sure they've been shown to be consistently worse, or better, than "standard" allo transplants, whether in myeloma or other blood cancers Instead, I think that the availability of stem cells from cord blood may be more limited that the availability of "standard" donated stem cells. I also wonder if there is an experience issue -- if doctors are a bit more hesitant to recommend the procedure because they just haven't done it as often.
In any case, the poster that Multibilly recommended looks like a good source of information. I also found this study from many of the same authors that discusses "double umbilical cord transplantation" in blood cancer patients -- basically, using a double dose of umbilical cord stem cells, rather than a single dose. It may be an option worth knowing about when you speak with your doctors.
HL Wallet et al., "Double umbilical cord blood transplantation for hematological malignancies: a long-term analysis from the SFGM-TC registry," Experimental Hematology, November 2013.
Abstract:
Allogeneic hematopoietic stem cell (HSC) transplantation is a curative treatment for many hematologic malignancies for which umbilical cord blood (UCB) represents an alternative source of HSCs. To overcome the low cellularity of one UCB unit, double UCB transplantation (dUCBT) has been developed in adults.
We have analyzed the outcome of 136 patients who underwent dUCBT reported to the SFGM-TC registry between 2005 and 2007. Forty-six patients received myeloablative regimens, and 90 patients received reduced-intensity conditioning regimens. There were 84 cases of leukemia, 17 cases of non-Hodgkin lymphoma, 11 cases of myeloma, and 24 other hematologic malignancies.
At transplantation, 40 (29%) patients were in complete remission. At day 60 after transplantation, the cumulative incidence of neutrophil recovery was 91%. We observed one UCB unit domination in 88% of cases. The cumulative incidence of day 100 acute graft-versus-host disease, chronic graft-versus-host disease, transplant-related mortality, and relapse at 2 years were 36%, 23%, 27%, and 28% respectively.
After a median follow-up of 49.5 months, the 3-year probabilities of overall and progression-free survival were 41% and 35%, respectively, with a significant overall survival advantage when male cord engrafted male recipients. We obtained a long-term plateau among patients in complete remission, which makes dUCBT a promising treatment strategy for these patients.
Re: Umbilical cord blood transplantation for myeloma?
We have a grandson expected in January, and his parents are not planning on banking the cord blood.
This has got me thinking, though, as my husband is currently on Revlimid / dex after relapsing from his 2011 autologous stem cell transplant.
Would a grandson / grandfather match be more likely than cord blood from a general blood bank if future research makes it possible to treat myeloma in this way?
This has got me thinking, though, as my husband is currently on Revlimid / dex after relapsing from his 2011 autologous stem cell transplant.
Would a grandson / grandfather match be more likely than cord blood from a general blood bank if future research makes it possible to treat myeloma in this way?
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Jainsie
Re: Umbilical cord blood transplantation for myeloma?
Great question Jainsie.
See:
http://www.nationalcordbloodprogram.org/donation/public_vs_private_donation.html
Even if not a match for your hubby, it would be a great thing for the parents to bank it publicly. If this program were around when my wife had our kids, I know we would have opted to do it.
See:
http://www.nationalcordbloodprogram.org/donation/public_vs_private_donation.html
Even if not a match for your hubby, it would be a great thing for the parents to bank it publicly. If this program were around when my wife had our kids, I know we would have opted to do it.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Umbilical cord blood transplantation for myeloma?
Hi Gracie,
About 10 yrs ago a neighbor, age 38, was diagnosed with multiple myeloma.
His wive was pregnant with twins. His hematologist suggested double umbilical cord transplant, which he received after his wife gave birth. He never had any other treatments afterwards and is still in complete remission. I certainly hope that his wish to dance with his daughters at their weddings will come true.
I was diagnosed with multiple myeloma in 1991 and have been without treatments for the past 8 yrs. multiple myeloma seems to take its own course with every patient. I am glad my doctor believes in observation - four times a year.
Best wishes,
Steiner
About 10 yrs ago a neighbor, age 38, was diagnosed with multiple myeloma.
His wive was pregnant with twins. His hematologist suggested double umbilical cord transplant, which he received after his wife gave birth. He never had any other treatments afterwards and is still in complete remission. I certainly hope that his wish to dance with his daughters at their weddings will come true.
I was diagnosed with multiple myeloma in 1991 and have been without treatments for the past 8 yrs. multiple myeloma seems to take its own course with every patient. I am glad my doctor believes in observation - four times a year.
Best wishes,
Steiner
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Steiner
Re: Umbilical cord blood transplantation for myeloma?
Thanks, multibilly and Steiner. Here in Canada there has been a program for parents to pay to have cord blood banked privately for some time. A national donor cord blood bank has now been set up by Canadian Blood Servces and will gradually expand to include more hospitals so I'll look into these options and will read the links you provided. Thanks again,
Jainsie
Jainsie
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jainsie
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