My recent immunofixation results showed large IgA kappa monoclones and small IgG kappa monoclones. Does this have any special meaning? Can you have two types of multiple myeloma, IgA and IgG?
I am being restaged after a 18 month remission and have experienced more back pain, fatigue, headaches and profuse sweating.
My awesome oncologist has ordered all the blood and urine tests and will do a bone marrow biopsy next week. SPEP results are 4.4 in gamma. Total proteins 9.7.
I am expecting that this means I have relapsed, just haven't heard of having two types of monoclones.
Forums
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
Re: Now have two m-spikes - IgA kappa & IgG kappa
Which immunoglobulin was the original protein?
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
Re: Now have two m-spikes - IgA kappa & IgG kappa
There is such a thing as biclonal gammopathy. However, I'm not sure it has any significance. I'm so sorry to hear of your possible relapse.
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
Re: Now have two m-spikes - IgA kappa & IgG kappa
Gracie: I'm not clear if the following pertains to your situation or not:
"Different M-Spike After Stem Cell Transplantation Linked To Improved Survival (ASH 2012)", The Myeloma Beacon, January 16, 2013.
"Different M-Spike After Stem Cell Transplantation Linked To Improved Survival (ASH 2012)", The Myeloma Beacon, January 16, 2013.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Now have two m-spikes - IgA kappa & IgG kappa
I had both IgA and IgG when I was diagnosed. I recently finished an auto transplant and both are gone and I have no detectable M spike at this time. Yet, weird thing is my tests said I had an IgM monoclonal band now but no M-spike. This seems weird to me and my doctor is having the results rechecked.
Anyhow, it is possible to have more than one type at the same time.
Best of luck to you.
Kim
Anyhow, it is possible to have more than one type at the same time.
Best of luck to you.
Kim
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kjpoppit - Name: Kim Nelson
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Sept. 19th, 2013
- Age at diagnosis: 47
Re: Now have two m-spikes - IgA kappa & IgG kappa
Boy, it sure seems like there are a fair number of folks on the Beacon that have biclonal (I use that term loosely here) gammopathies with different heavy chains, biclonal gammopathies with different free light chains, banding, oligoclonal banding, etc. Some have this situation pre-SCT, post-SCT and even at the MGUS stage. Just based on the number of posts I've come across recently, it strikes me that this is more common than the 1% or so of cases that one sees in the literature.
I'm also frankly confused by the differences in all these variations and whether biclonal gammopathies are the same as the "banding" pheonomena and what the prognostic significance is of each variation.
There are also some great questions that have recently come up regarding how to deal with FLC ratios and values if you have a biclonal gammopathy that involves both kappa and lambda, how to reconcile the supposed goodness of having banding occur post-SCT (esp if one is trying to get to sCR with no M-Spike, etc).
Beacon Staff, perhaps you might be able to help us sort this all out?
I'm also frankly confused by the differences in all these variations and whether biclonal gammopathies are the same as the "banding" pheonomena and what the prognostic significance is of each variation.
There are also some great questions that have recently come up regarding how to deal with FLC ratios and values if you have a biclonal gammopathy that involves both kappa and lambda, how to reconcile the supposed goodness of having banding occur post-SCT (esp if one is trying to get to sCR with no M-Spike, etc).
Beacon Staff, perhaps you might be able to help us sort this all out?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Now have two m-spikes - IgA kappa & IgG kappa
Interesting you should post this, Multibilly, because we just sent out an inquiry earlier this afternoon to clarify something in regard to one of the recent questions on this general topic.
We'll let you know what we hear back and also look into getting feedback on some of the other related questions that have been raised (and which you've mentioned).
Thanks!
We'll let you know what we hear back and also look into getting feedback on some of the other related questions that have been raised (and which you've mentioned).
Thanks!
Re: Now have two m-spikes - IgA kappa & IgG kappa
Post transplant my husband had a 0.1 spike of IgM (his original m spike was IgA). Over the last couple months he has had no m spike but banding of IgM, sometimes more then one band. However, his original IgA has never reappeared on any of the tests and some months this new band of IgM is there and sometimes not.
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
Re: Now have two m-spikes - IgA kappa & IgG kappa
Thanks for all of your responses!
My original m-spike was IgA (4.4). So my m-protein didn't change, but a small amount of monoclonal IgG proteins were identified this time. IgA was found to be in large amounts.
My IgA is elevated over 3,000 (469 in May) and my IgG is falling 800 (1319 in May). Both are kappa.
My original m-spike was IgA (4.4). So my m-protein didn't change, but a small amount of monoclonal IgG proteins were identified this time. IgA was found to be in large amounts.
My IgA is elevated over 3,000 (469 in May) and my IgG is falling 800 (1319 in May). Both are kappa.
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
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