[blair77]

Treatment for early relapse after auto SCT?

by blair77 on Tue May 06, 2014 3:36 pm

I am wondering if anyone has relapsed from CR [complete response] "early" (less then 12 months) after their autologous stem cell transplant (ASCT)?

What treatment plan was taken and was it successful?

[blair77]

Re: Treatment for early relapse after auto SCT?

by blair77 on Wed May 07, 2014 11:24 am

Has anyone has this experience or read articles on this subject?

[cyom22]

Re: Treatment for early relapse after auto SCT?

by cyom22 on Wed May 07, 2014 7:15 pm

My first stem cell transplant lasted one year, but I became a non secretor and developed plasmocytomas in jaw. Then I had CyBorD [cyclophosphamide, Velcade, and dexamethasone] for 6 months, and then a second stem cell transplant, which didn't work.

Now being treated with Pomalyst [pomalidomide, Imnovid] and dexamethasone for the last 9 months. It seems to be holding me stable . I'm having a PET-CT next week for my third checkup.

Best wishes.

[Dr. Edward Libby]

Re: Treatment for early relapse after auto SCT?

by Dr. Edward Libby on Thu May 08, 2014 12:09 am

Hello Blair77,

Unfortunately, early relapse (< 1 year) post stem cell transplant can happen. This is more often true when a patient has high risk cytogenetics, such as the p53 deletion or translocation t(4;14).

Patients can be salvaged with any number of different treatment regimens depending on what worked before transplantation and what drugs you have received so far. Early relapse patients can be brought into a remission again, but, unfortunately, early relapse post stem cell transplant can be a poor prognostic sign.