I've been researching using 8g of curcumin as a means to keep my smoldering myeloma just "smoldering" and nothing more. My hematologist and his pharmaceutical and nutritional staff are also investigating it for me per my request. However, I came across this article which now has me wondering just how safe high-dose curcumin really is in the long run.
http://onlinelibrary.wiley.com/doi/10.1002/ijc.24967/pdf
You may have also heard about the ongoing investigation by MD Anderson into one of their researchers involved in their earlier curcumin study (see below). Be clear, that nothing is settled here and everyone is innocent until proven guilty, but the above two items do raise concerns in my mind regarding going down a path of using high dose curcumin.
http://retractionwatch.wordpress.com/2012/01/31/md-anderson-investigating-researcher-bharat-aggarwal-over-images/
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: The dark side of curcumin?
Fresh off the press from China. Synthetic curcumin.
http://file.scirp.org/pdf/JCT_2013020711192822.pdf
http://file.scirp.org/pdf/JCT_2013020711192822.pdf
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: The dark side of curcumin?
Curcumin has a very low toxicity:
From this book by Dr. Murray, N.D. (naturopathic doctor): http://books.google.com/books?id=UmkOD1YIqXYC&pg=PA173 :
"Is curcumin safe?
"Curcumin has an excellent safety profile. In fact, no lethal dose has been reached in animal studies.²⁰ Curcumin at a dosage of 2.5 g/kg fet to mice, rats, guinea pigs, and monkeys produced no mortality or genetic mutations in offspring."
From this book by Dr. Murray, N.D. (naturopathic doctor): http://books.google.com/books?id=UmkOD1YIqXYC&pg=PA173 :
"Is curcumin safe?
"Curcumin has an excellent safety profile. In fact, no lethal dose has been reached in animal studies.²⁰ Curcumin at a dosage of 2.5 g/kg fet to mice, rats, guinea pigs, and monkeys produced no mortality or genetic mutations in offspring."
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Geremia - Who do you know with myeloma?: mother
- When were you/they diagnosed?: 1/30/2014
- Age at diagnosis: 60
Re: The dark side of curcumin?
Thank you for the info, multibilly, as usual.
My mom remains at only 1gram of curcumin daily. I have been meaning to increase it, but at the same time, have not found a reason to do so, even though we know that most people eventually ramp it up to 4 grams or more.
My mom remains at only 1gram of curcumin daily. I have been meaning to increase it, but at the same time, have not found a reason to do so, even though we know that most people eventually ramp it up to 4 grams or more.
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dnalex - Name: Alex N.
- Who do you know with myeloma?: mother
- When were you/they diagnosed?: 2007
- Age at diagnosis: 56
Re: The dark side of curcumin?
Maybe you should look into liposomal. It is a vastly superior delivery system. Mgs work like grams. Absolute best value for your dollar. Read the reviews and studies of the lipo vs piperine curcumin. Absolutely eliminated my neuropathy pain for the last 3 years, waaaay better than any of the pills I tried, and if works that much better for inflammation.
Re: The dark side of curcumin?
KC, if you don't mind me asking, what brand liposomal curcumin do you use and what sort of dose do you take daily?
When searching on "liposomal curcumin", I came across these research articles.
http://www.ncbi.nlm.nih.gov/pubmed/19528445
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206621/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259195/
When searching on "liposomal curcumin", I came across these research articles.
http://www.ncbi.nlm.nih.gov/pubmed/19528445
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206621/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259195/
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
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