Hello,
I have IgG kappa and IgG lambda monoclonal gammopathy and they are both increasing in relatively parallel increments. Does this mean that the free light chain (FLC) ratio, which is most often considered for risk and qualification for clinical trials in smoldering myeloma, will never be a number that is reliable in my case?
There is a lot of emphasis placed on this value, so I'm wondering if it has any significance in a case of biclonal gammopathy of the same immunoglobulin?
Thanks!
J
Forums
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jhorner - Name: Magpie
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 2013
- Age at diagnosis: 49
Re: Is FLC ratio reliable in biclonal gammopathy?
Yes, it will be difficult to use the FLC ratio in your case, as both kappa and lambda will be elevated. If one starts to really take off compared with the other, then this would be informative, but otherwise I don't think it will be very helpful for risk stratification purposes.
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Dr. Adam Cohen - Name: Adam D. Cohen, M.D.
Beacon Medical Advisor
Re: Is FLC ratio reliable in biclonal gammopathy?
I am wondering if the newly FDA approved HevyLite assay (the Binding Site) would be a more useful tool in a biclonal gammopathy?
Any thoughts on its utility in this situation as related to risk stratification?
Many thanks,
Dana H
Any thoughts on its utility in this situation as related to risk stratification?
Many thanks,
Dana H
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DanaH - Who do you know with myeloma?: Myself, SMM as of 1/2012
- When were you/they diagnosed?: 1/2012
- Age at diagnosis: 54
Re: Is FLC ratio reliable in biclonal gammopathy?
What is the Hevylite test ? Is it a blood test like the free light chain test?
Thanks.
Thanks.
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Anonymouss
Re: Is FLC ratio reliable in biclonal gammopathy?
Hi Anonymouss,
Yes, the HevyLite Assay is a new test from the same company that developed the Freelite assay used for determining free light chain levels.
You can read more about the HevyLit assay at these links:
http://www.thebindingsite.com/news?story=402
From the above link: "The Hevylite assays are a family of novel tests that can distinguish and quantify specific intact heavy/light chain combinations from myeloma clones, including cases where traditional electrophoretic techniques are insufficiently sensitive. The sensitivity of Hevylite makes it a potentially valuable tool for serial monitoring treatment in patients with IgG and IgA myeloma as Hevylite may help identify early relapse and residual disease."
http://www.thebindingsite.com/hevylite
http://www.wikilite.com/wiki/index.php/Analysis_of_Ig_heavy_chain/light_chain_pairs_(Hevylite%E2%84%A2)
Yes, the HevyLite Assay is a new test from the same company that developed the Freelite assay used for determining free light chain levels.
You can read more about the HevyLit assay at these links:
http://www.thebindingsite.com/news?story=402
From the above link: "The Hevylite assays are a family of novel tests that can distinguish and quantify specific intact heavy/light chain combinations from myeloma clones, including cases where traditional electrophoretic techniques are insufficiently sensitive. The sensitivity of Hevylite makes it a potentially valuable tool for serial monitoring treatment in patients with IgG and IgA myeloma as Hevylite may help identify early relapse and residual disease."
http://www.thebindingsite.com/hevylite
http://www.wikilite.com/wiki/index.php/Analysis_of_Ig_heavy_chain/light_chain_pairs_(Hevylite%E2%84%A2)
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